Recent breakthrough in the field of Chemistry

Nobel-prize won in Chemistry for clean energy breakthrough1:

In 2017, Nobel Prize in Chemistry was awarded to Joachim Frank, Richard Henderson and Jacques Dubochet for their role in developing the technique of 'single particle reconstruction'. This electron microscopy technique has helped in revealing the structures of a huge number of viruses and proteins but not usually used for metals uptil recently.

Recently, Scientists have used this technique on a mixture of metals to potentially reduce the cost of fuel cells used in electric cars and reduce harmful emissions from conventional vehicles. A team at the University of Manchester, in collaboration with researchers at the University of Oxford and Macquarie University, have built upon this technique to produce three dimensional elemental maps of metallic nanoparticles consisting of just a few thousand atoms overcoming damage to the particles studied.

The work published in the journal Nano Letters, comprises of the study to new 3D chemical imaging method used to investigate platinum-nickel (Pt-Ni) metal nanoparticles.

Novel synthesis of fluorinated piperidines2:

Synthetic molecules are the basic component for many products in our lives including medicines among others. These molecules have several components, which can be combined in a variety of ways, resulting in different properties. Among which, piperidines and fluorinated groups are particularly important. Piperidines are small, ring-shaped chemical compounds. Since, fluorine atoms have some particular properties, so they bring about dramatic changes in the properties of certain products and are often integrated in pharmaceuticals. Hence, around twenty percent of all medicines sold worldwide contain fluorine.

Uptil now, combining fluorine atoms and piperidines has always been an extremely tedious process. For the first time, chemists at the University of Münster have developed novel and facile synthesis method for producing fluorine-bearing piperidines. The study has been published in the online edition of the Nature Chemistry journal and was carried out by Dr. Zackaria Nairoukh, Marco Wollenburg, Dr. Christoph Schlepphorst, Dr. Klaus Bergander and Prof. Frank Glorius. In 2017, the Münster chemists had already published a study in journal Science, in which they presented a method by which cyclic, fluorinated molecules could be produced conveniently.

 

References:

[1] Yi-Chi Wang, Thomas J. A. Slater, Gerard M. Leteba, Alan M. Roseman, Christopher P. Race, Neil P. Young, Angus I. Kirkland, Candace I. Lang, Sarah J. Haigh. Imaging Three-Dimensional Elemental Inhomogeneity in Pt–Ni Nanoparticles Using Spectroscopic Single Particle Reconstruction. Nano Letters, 2019; DOI: 10.1021/acs.nanolett.8b03768.

[2] Zackaria Nairoukh, Marco Wollenburg, Christoph Schlepphorst, Klaus Bergander, Frank Glorius. The formation of all-cis-(multi)fluorinated piperidines by a dearomatization–hydrogenation process. Nature Chemistry, 2019; DOI: 10.1038/s41557-018-0197-2.